COMPARATIVE IN-VITRO BIOEQUIVALENCE STUDIES OF SOME BRANDS OF METRONIDAZOLE TABLET MARKETED IN ZARIA, KADUNA STATE
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
Metronidazole is an antibacterial and antiprotozoal drug used in the treatment of amebiasis, giardiasis, trichomoniasis and other microbial diseases. It is an essential drug commonly found in Nigerian market and has so many generics and dosage forms under various trade names by different manufacturers. The purpose of the study was to evaluate and compare the in-vitro bioequivalence of branded and generic metronidazole tablet in three different physiological media (pH 1.2, 4.5 and 6.8). Six brands of metronidazole tablet were randomly selected from different areas of Zaria town and evaluated for quality via identification test, assay, weight variation test, disintegration time test, friability, crushing strength and dissolution. Three UV spectrophotometric methods were developed, validated and used for determining the amount of metronidazole release during the in-vitro dissolution studies. The percentage of metronidazole released was then subjected to in-vitro bioequivalence comparison using the model independent method of comparism. The results showed that all brands passed identification an assay test except brand MD and ME that failed the assay test. The tested brands passed weight variation test, disintegration time test, friability and hardness except brand ME which failed the hardness test. Wavelength of maximum absorbance (ĘŽmax) of 295nm, 345nm and 350nm were recorded for metronidazole in pH media 1.2, 4.5 and 6.8 respectively, with a linear relation at concentration range of 2-64𝜇g/mL. The correlation coefficients were close to unity with percentage recoveries ranging from 98-102% and precision (% CV) 50; therefore, can be used interchangeable with brand MA in all the three simulated physiological media. Also, brand MF had similar dissolution profile with MA in two physiological media (pH 1.2 and 4.5) but not in pH 6.8. However, the dissolution viii profile of brand MD and brand ME were not similar with brand MA in all the three media. The percentage dissolution efficiency (DE) of all the brands in all the three media were within the acceptable limit of ±10%. It was concluded that the branded MA could be interchanged with brand MB and brand MC in all the three media and with brand MF in pH 1.2 and pH 4.5 but not in pH 6.8 and also not with brand MD and brand ME in all the three media.
Related Project Materials
THE IMPACT OF ENVIRONMENTAL FACTORS ON PROJECT MANAGEMENT
Abstract: This study investigates the impact of environmental factors on project management, aiming to: 1) i...
STRATEGIES FOR PROMOTING INTERDISCIPLINARY COLLABORATION IN VOCATIONAL EDUCATION
Abstract: In recent years, the demand for interdisciplinary skills in vocational education...
INDUSTRIAL RELATIONS AS A STRATEGY FOR ENHANCING ORGANIZATIONAL PERFORMANCE IN PEUGEOT AUTOMOBILE NIGERIA LIMITED
ABSTRACT
The study emphasizes on the success and effectiveness of industrial relations towards enhancing organizatio...
EXAMINING INNOVATIONS IN VOCATIONAL EDUCATION FOR CAREERS IN BIOTECHNOLOGY
ABSTRACT: Innovations in vocational education for careers in biotechnology are critical for equipping students with the necessary skills to th...
EFFECTS OF CONCEPTUAL CHANGE INSTRUCTIONAL STRATEGIES ON SECONDARY SCHOOL STUDENTS’ MISCONCEPTIONS, PERFORMANCE AND RETENTION IN GENETICS IN NIGERIA
ABSTRACT
The study examined the Effects of Conceptual Change Instructional Strategies on Secondary Students‟ Misconceptions, Performance...
ELECTRONIC MOBILIZATION AND NIGERIA GENERAL ELECTION: A CASE STUDY OF FACEBOOKÂ ANDÂ WHATSAPP
​​​​​​Background of the study
The Nigerian 2015 general elections was a significant departure from the...
A CRITICAL ANALYSIS OF THE IMPACT OF TWITTER’S BAN ON GOVERNMENT TRANSPARENCY AND ACCOUNTABILITY
ABSTRACT
This study was carried out to critic...
THE IMPACT OF AE FUNAI ON THE SOCIO-ECONOMIC DEVELOPMENT OF IKWO LGA (2013-2023)
CHAPTER ONE
INTRODUCTION
​​​​​​​Background of the study
Institutio...
EVALUATION OF SOME CHEMICAL CONSTITUENTS OF SELECTED ENERGY DRINKS
Abstract
This research work examined and compares the physicochemical properties and some chemical cons...
IMPACT OF BROKEN HOMES ON ACADEMIC PERFORMANCE OF STUDENTS IN KADUNA NORTH LOCAL GOVERNMENT AREA OF KADUNA STATE
Background of the Study
The institution of education has been recognized as having significant value t...
